The White Blood Cells didn't have much to do, but they were aware the body was ripe for thrombosis and blood clots in its legs. Sure enough, the red blood cells started clotting and AA2153 and his buddy needed to work hard to stop a pulmonary embolism from suffocating the lungs. There are other bad signs about how badly the body is doing, like how the hepatocytes in the liver are started to die off and U-1196 noticed her white blood cell sisters were missing.
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